Twenty-three bacteriologically positive leprosy patients were randomly selected
from a leprosarium, randomly divided into four treatment groups, and given var-
ying dosages of Isoprodian, the tablet contained INAH 175mg, Prothionamide
175mg and DDS 50 mg, for five months. Group I: Initial´ tablet dose per week
with 2 tablet increment every 2 weeks until 12 tablets were being consumed wee-
kly. Group II: Initial 1 tablet dose per week with 1 tablet increment every 2 weeks
until 12 tablets were being consumed weekly. Group III: Initial 2 tablet dose per
week with 2 tablet weekly increment until 12 tablets were being consumed weekly
Group IV: Initial 1 tablet dose per week with 1 tablet weekly increment until 12
tablets were being consumed weekly.
The therapeutic results obtained were as follows:
A) Bacteriological results
1) Bacteriological Index (BI) : Group I: average reduction of 0.2 unit. Group II:
average reduction of 0.97 unit. Group III: average reduction of 0.9 unit. Group
i IV: average reduction of 1.0 unit. Authors conclude that the group III drug reg-
imen was the most beneficial, yielding favorable bacteriological results with the
least number of untoward side effects.
2) Morphological Index (MI) : Reduced to baseline within an average of 4 to 12
weeks.
+ 3) Granularity Index (GI) : Group I: 1.8 increment. Group II: 0.5 increment. Group
III: 1.1 increment. "Group IV: 1.76 increment.
B) During treatment, different side-effects were observed in all 23 patients, The
most frequent side-effect was dizziness, observed in 17 patients. Two patients
expired: one from pulmonary tuberculosis, and the other, presumably, from
toxic hepatitis.
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